Inflammation and Oxidative Stress: Understanding the Core Mechanisms Guiding Next-Generation Drug Development in Neuroprotection
The failure of early-generation neuroprotective drugs, which often targeted single pathways like the NMDA receptor, highlighted a fundamental truth: neurodegeneration is a complex, multi-mechanistic process. This realization has redirected research toward core, pervasive mechanisms of neuronal injury, chiefly chronic neuroinflammation and oxidative stress. Microglial activation, the brain's...
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