The Her2-Low Paradigm: Expanding the Target Population in Her2 Positive Breast Cancer Treatment One of the most exciting recent developments is the successful expansion of Her2-targeted therapy beyond the traditionally defined Her2-positive population to include patients with "Her2-low" expression. Her2-low is defined as a tumor that expresses a low level of the Her2 protein (IHC 1+ or IHC 2+/FISH negative), which was previously treated as Her2-negative, severely limiting therapeutic...
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